Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Effectiveness of Monovalent mRNA Vaccines Against COVID-19-Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States – IVY Network, 18 States, December 26, 2021-August 31, 2022Article Published on 2022-10-212022-11-16 Journal: Morbidity and Mortality Weekly Report [Category] COVID19(2023년), SARS, 변종, [키워드] accounted Against B.1.1.529 booster dose category COVID-19 vaccine dose Effectiveness eligible adult estimate expected Hospitalization Immunity immunocompetent adult immunogenic include Infection Interpretation Lineage lineages majority monovalent mRNA mRNA component mRNA COVID-19 vaccine mRNA vaccine network omicron overlapped Period predominant Prevent protection receive reduce replaced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain second dose the United State vaccination Vaccine Vaccine-induced immunity variant waned [DOI] 10.15585/mmwr.mm7142a3 PMC 바로가기
Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Affect Alter antibody Antibody Response Antigen antigen exposure antigenic B.1.1.529 boost chronic conditions chronic infection clinical history Cohort COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibody cross-reactivity defined described detectable Diseases epitope glycoprotein healthy high mutation rate highly antigenic immune response immunogenic individual mechanism mutations naïve individual neurological omicron overlapped Pathogens resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike protein serum antibody severe COVID-19 specificity Spike protein Subsequent infection target the antibody response understanding vaccination variants of SARS-CoV-2 Viral antigen virus virus viruses [DOI] 10.1038/s41598-022-20849-6 PMC 바로가기
Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failureResearch article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used [DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article
Ongoing Mycophenolate Treatment Impairs Anti-SARS-CoV-2 Vaccination Response in Patients Affected by Chronic Inflammatory Autoimmune Diseases or Liver Transplantation Recipients: Results of the RIVALSA Prospective Cohort진행중인 미코페놀레이트 치료는 만성 염증성 자가면역 질환 또는 간 이식 수혜자의 영향을 받는 환자에서 항-SARS-CoV-2 백신 반응을 손상시킵니다: RIVALSA 예상 코호트의 결과Observational Study Published on 2022-08-122022-09-11 Journal: Viruses [Category] SARS, 임상, 진단, 치료기술, [키워드] 95% CI administration Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccination Antibody Response Antibody titers ARMS Arthritis Autoimmune Autoimmune disease Autoimmune diseases Autoimmune hepatitis calcineurin calcineurin inhibitors chronic cohort of patients Complete connective tissue disease Connective tissue diseases detectable develop Diagnosis dose dose reduction Effect effective Eligible patients enrolled evaluate evaluated example first dose healthy subjects hepatology identify IgG immunogenicity immunosuppressive immunosuppressive therapy Immunosuppressive treatment independent predictor independent predictors individual inhibitor liver liver transplant Liver transplantation MMF mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine mRNA-based Multivariate analysis mycophenolate mycophenolate. neoplasia Novara observational study organ other diseases overlapped Patient patients performed predictor Prevent Prospective prospective observational study receiving recipients rejection required response Result rheumatoid arthritis rheumatological SARS-COV-2 infection selected Seroconversion seroconversion failure spondyloarthritis subgroups of patient suffered Suspension Tertiary therapy transplantation transplants treated Treatment unit Univariate analysis university vaccinated individual vaccination Vaccine vaccine response Vasculitis [DOI] 10.3390/v14081766 PMC 바로가기 [Article Type] Observational Study
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Drug-Target Network Study Reveals the Core Target-Protein Interactions of Various COVID-19 TreatmentsArticle Published on 2022-07-062022-10-04 Journal: Genes [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis Bronchoalveolar lavage fluid cascade caused Cell cell membrane conducted core coronavirus disease COVID-19 COVID-19 symptom CTD curated database death rate Diseases downstream cellular signaling drug Drug discovery drug treatment drug-target drug-target network drugs effort function Genes Human interconnected genes involved knowledge lung Macrophage medications mitigate network Numerous overlapped overlapping pandemic pharmacological target PPI protein-protein interaction receptors reduce risk SARS-CoV-2 virus severe COVID-19 significantly single-cell Symptom T cell target gene text mining Text mining. [DOI] 10.3390/genes13071210 PMC 바로가기 [Article Type] Article
Identification of critical genes and molecular pathways in COVID-19 myocarditis and constructing gene regulatory networks by bioinformatic analysis코로나19 심근염의 핵심 유전자 및 분자경로 규명 및 생물정보분석을 통한 유전자 조절 네트워크 구축Article Published on 2022-06-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] adjusted Algorithms Analysis analysis bioinformatic analysis bioinformatics biological processe biological processes CDC20 CDK1 Cell cell cycle Compound correlation COVID-19 Critical Cytoscape dataset DEGs differentially expressed gene down-regulated genes drug drugs enrichment analysis etoposide Evidence evidence of fold Functional enrichment analyses Functional enrichment analysis Gene Expression Gene Expression Omnibus gene regulatory network Genes GEO highlighting hydrolysis identification identify in vitro indicated infected with SARS-CoV-2 Interaction KIF20A KIF2C mechanism methotrexate molecular myocarditis network analysis overlapped P-value Pathogenesis pathway Patient PBK performed Perspective pluripotent stem cell Potential biomarker potential biomarkers PPI probe protein-protein interaction provide R software Regulatory signature target transcription factor Treatment Troglitazone turquoise module UBE2C up-regulated was used website were assessed WGCNA with COVID-19 [DOI] 10.1371/journal.pone.0269386 PMC 바로가기 [Article Type] Article
Epidemiological and Clinical Features of Kawasaki Disease During the COVID-19 Pandemic in the United States미국의 코로나19 팬데믹 동안 가와사키병의 역학적 및 임상적 특징Multicenter Study Published on 2022-06-012022-09-12 Journal: JAMA Network Open [Category] MERS, 진단, [키워드] affected age ambient Analysis Asian baseline children circulation clinical Clinical data clinical feature Cohort collected Community Compliance COVID-19 COVID-19 pandemic decrease desquamation diagnosed Diego Diseases Effect epidemiological etiology evaluate Factor feature Fever Health Hispanic Hypothesis incidence indicated intensity Kawasaki disease Lymph node male Mask mandates measure median Mobility multicenter multicenter cohort study outcome overlapped pandemic Patient pediatric Prevalence provided Public public health measure reduce remained respiratory virus School the mean the United State The United States tongue Transmission Vasculitis was collected white widespread [DOI] 10.1001/jamanetworkopen.2022.17436 PMC 바로가기 [Article Type] Multicenter Study
A screening strategy for identifying the dominant variant of SARS-COV-2 in the fifth peak of Kurdistan- Iran population using HRM and Probe-based RT-PCR assayHRM 및 프로브 기반 RT-PCR 분석을 사용하여 쿠르드-이란 인구의 다섯 번째 피크에서 SARS-COV-2의 우세한 변이를 식별하기 위한 스크리닝 전략Article Published on 2022-06-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 변종, [키워드] caused country D614G D614G mutation Del69-70 mutation diagnostic test dominant variant E484K E484K mutation E484Q mutation genomic Genomic surveillance high resolution HRM identify indicated Iran Kurdistan L452R L452R mutation melting mortality rate Mutation operation overlapped positive patient probe Probe-based RT-PCR reduce Resolution RT-PCR RT-PCR assay SARS CoV SARS CoV-2 SARS-CoV-2 positive patients screened screening strategy Sequencing suggested Surveillance T478K T478K mutation. Transmissibility variant variants whole-genome sequencing [DOI] 10.1016/j.jviromet.2022.114514 PMC 바로가기 [Article Type] Article